Liraglutide is in SAXENDA. It is a human GLP-1 copy that acts as a GLP-1 receptor agonist. The peptide precursor of liraglutide is made by expressing recombinant DNA in Saccharomyces cerevisiae. The 34th position has been changed from lysine to arginine to make it 97% identical to natural human GLP-1. Liraglutide is made by adding a C-16 fatty acid (palmitic acid) and a glutamic acid spacer to the peptide precursor’s last remaining lysine residue at position 26.

Dosage Forms and Strengths:

SAXENDA is a clear solution that has no color. The amount of liraglutide in 1 mL of SAXENDA solution is 6 mg. Each SAXENDA® pre-filled pen has a 3 mL solution of liraglutide, which is equal to 18 mg (free-base, anhydrous).

Usual dose:

When you start taking SAXENDA for the first time, you take 0.6 mg once a day. After a week of taking SAXENDA®, your dose should be raised until you reach the 3.0 mg dose. After that, you should only change your dose if your doctor tells you to. SAXENDA is given by injection once a day, at any time. SAXENDA can be taken with food or on an empty stomach. When you start taking SAXENDA, your doctor should give you a plan for how to eat and move. Follow this plan as long as you are taking SAXENDA.


SAXENDA (liraglutide) is meant to be used with a low-calorie diet and more exercise to help adults with a body mass index (BMI) of: 30 or higher lose weight and keep it off.
30 kg/m2 or greater (obese), or
27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes, or dyslipidemia) and who have failed a previous weight management intervention.eased further to 1.8mg daily.


SAXENDA is a solution for subcutaneous injection that comes in a multi-dose pen that can deliver doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg, or 3.0 mg (6 mg/mL, 3 mL).


  • feeling sick (nausea), being sick (vomiting), diarrhea, constipation these usually go away after a few days or weeks
  • lower appetite
  • problems affecting the stomach and intestines such as: indigestion (dyspepsia), inflamed lining of the stomach (gastritis), stomach discomfort, upper stomach pain, heart burn, Feeling
  • bloating, wind (flatulence), belching, dry mouth
  • feeling weak or tired
  • changed sense of taste
  • dizziness
  • gallstones
  • injection site reactions (such as bruising, pain, irritation, itching and rash)
  • low blood sugar (hypoglycemia) the warning signs of low blood sugar may come on suddenly.


  • Do not use SAXENDA after the date on the label and the carton says it is no longer good. The date of expiration means the last day of the month.
  • Before you start taking SAXENDA, keep it in a refrigerator (between 2oC and 8oC), but not in the freezer. Do not freeze it.
  • SAXENDA can be kept for 1 month at room temperature (as long as it doesn’t get above 30oC) or in a refrigerator (2oC to 8oC).
  • If SAXENDA has been frozen, don’t take it.
  • After each injection, you should always take the injection needle out and store your SAXENDA pen without the injection needle attached.
  • This keeps the area from getting dirty, infected, or leaking. It also makes sure that the right amount is given.
  • Keep the pen’s cap on when you’re not using it. This will keep the medicine from getting too much light. Keep SAXENDA away from heat and direct sunlight.
  • Medicines should not be thrown away with the trash or used water. Talk to your pharmacist about how to get rid of medicines you no longer need. The environment will be safer because of these steps.
  • Keep out of children’s reach and sight.


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